Search results for "Post-tetanic potentiation"

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Reduced presynaptic efficiency of excitatory synaptic transmission impairs LTP in the visual cortex of BDNF-heterozygous mice

2006

The neurotrophin brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival, axonal and dendritic growth and synapse formation. BDNF has also been reported to mediate visual cortex plasticity. Here we studied the cellular mechanisms of BDNF-mediated changes in synaptic plasticity, excitatory synaptic transmission and long-term potentiation (LTP) in the visual cortex of heterozygous BDNF-knockout mice (BDNF(+/-)). Patch-clamp recordings in slices showed an approximately 50% reduction in the frequency of miniature excitatory postsynaptic currents (mEPSCs) compared to wild-type animals, in the absence of changes in mEPSC amplitudes. A presynaptic impairment of excita…

N-MethylaspartatePatch-Clamp TechniquesTime FactorsLong-Term PotentiationPresynaptic TerminalsAMPA receptorIn Vitro TechniquesSynaptic TransmissionMicePostsynaptic potentialQuinoxalinesExcitatory Amino Acid AgonistsAnimalsalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidVisual CortexMice KnockoutNeuronsBrain-derived neurotrophic factorDose-Response Relationship DrugPost-tetanic potentiationChemistryBrain-Derived Neurotrophic FactorGeneral NeuroscienceDose-Response Relationship RadiationLong-term potentiationElectric StimulationSynaptic fatigueAnimals Newbornnervous systemSynaptic plasticityExcitatory postsynaptic potentialCalciumExcitatory Amino Acid AntagonistsNeuroscienceEuropean Journal of Neuroscience
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